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Research Roundup Exposure Banding/OELs (AIHce EXP 2021 OnDemand)
Course Description:
Recorded at AIHce EXP 2021

Derivation of an Occupational Exposure Limit for Diacetyl Using Dose‐response Data from a Chronic Animal Inhalation Exposure Study

An 8-hour time-weighted average (TWA) occupational exposure limit (OEL) for diacetyl was derived based on data from a chronic, 2-year animal inhalation study released by the U.S. National Toxicology Program, in lieu of existing epidemiological data. Benchmark concentration (BMC) modeling of histopathological endpoints in mice and rats exposed to 0, 12.5, 25, or 50 ppm diacetyl was conducted. After modeling, BMCL[sub]10[/sub]s based on responses in the lower respiratory tract of rats were chosen as the critical endpoints of interest and were subsequently converted to human equivalent concentrations (HECs). Application of a composite uncertainty factor yielded 8 hour TWA OEL values with a range of 0.16‐0.70 ppm, yielding a recommended 8 hour TWA OEL of 0.2 ppm based on minimal severity of bronchiolar epithelial hyperplasia in the rat.

Presenter/Author: Evan Beckett, MPH, CIH, Cardno ChemRisk, Boston, MA
Co-Authors: W. Cyrs, Cardno ChemRisk, San Francisco, CA, USA A. Abelmann, Cardno ChemRisk, Chicago, IL, USA A. Monnot, Cardno ChemRisk, San Francisco, CA, USA S. Gaffney, Cardno ChemRisk, San Francisco, CA, USA B. Finley, Cardno ChemRisk, Brooklyn, NY, USA

Assessment of Impacts on the Lung of Long-term Exposure to Copper-Containing Dust at a Copper Smelter - Historical Spirometry Data, Examination via Body Plethysmography and Inflammatory Biomarkers in Blood and Sputum

Occupational exposure limits for Cu dusts are subject to discussion towards significantly lower permissible levels in Europe and North America. Since human data are rarely reported, animal studies dominate the standard-setting processes. Addressing this issue, a historical cohort study was performed in 2018 on workers at a copper smelter. Possible effects of long-term exposures to dusts containing Cu on lung function were assessed based on spirometry data from medical surveillance examinations. Specifically, declines in FEV1 were compared between copper exposed and reference groups. Historical exposures were estimated based on airborne monitoring data and cumulative copper exposures were derived for each subject. To add to the historical data, in 2019 a cross-section of currently employed volunteers was examined for impacts on lung function (via body plethysmography) and signs of inflammation (via differential cell counts and biomarkers in blood and sputum, and exhaled nitric oxide).

Presenter/Author: Lisa-Marie Haase, Ramboll Deutschland GmbH Essen, North Rhine-Westphalia Germany
Co-Authors: T. Birk, Ramboll Deutschland GmbH, Essen, North Rhine-Westphalia, Germany A. Bachand, Ramboll US Corporation, Amherst, Massachusetts, USA O. Holz, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hanover, Lower Saxony, Germany C. Poland, University of Edinburgh, Edinburgh, Scotland, UK

Contact Hours:
1

Presentation Date:
05/26/2021

Session recordings are available for 90 days from purchase.


Stock #: AOD21_K1
ISBN #: 
Author/Editor: 

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