Disinfection is recognized as an important aspect of infection prevention, especially for Healthcare Acquired Infections (HAIs) caused by certain microorganisms such as Clostridium difficile on environmental surfaces. Determining appropriate disinfection of environmental surfaces requires balancing several factors including risk, efficacy, patient and worker safety and comfort, surface and process compatibility, and cost. New products and processes for disinfection are creating opportunities for industrial hygienists to apply their expertise.